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J&J’s one-dose shot was accepted, making the US the third country to receive the COVID-19 vaccine.

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J&J's one-dose shot was accepted, making the US the third country to receive the COVID-19 vaccine.

 

The Food and Drug Administration approved a Johnson & Johnson shot that works with only one dose instead of two to prevent COVID-19 in the United States on Saturday.

As they race against a virus that has already killed over 510,000 people in the United States and is mutating in increasingly alarming ways, health experts are eagerly awaiting a one-and-done solution to help accelerate vaccinations.

According to the FDA, J&J’s vaccine provides good protection against the most serious infections, hospitalizations, and death. In a wide study spanning three continents, one dose was found to be 85 percent protective against the most serious COVID-19 illness — safety that remained high even in countries like South Africa, where the most troubling variants are spreading.

Dr. Francis Collins, director of the National Institutes of Health, told The Associated Press on Saturday, “This is very good news.” “Right now, the most important thing we can do is get as many shots into as many guns as possible.”

J&J would initially have a few million doses, with shipments to states starting as soon as Monday. J&J has announced that it plans to supply 20 million doses to the United States by the end of March, and 100 million by the summer.

J&J is also seeking approval from the World Health Organization and the European Commission for the emergency use of its vaccine. By the end of the year, the company expects to have produced around 1 billion doses worldwide. Bahrain, an island nation, was the first to accept its use on Thursday.
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President Joe Biden said in a statement, “This is exciting news for all Americans and a promising step in our efforts to end the crisis.” “But let me be clear: this war is far from over,” he said, urging people to continue wearing masks and taking other public-health precautions.

A US advisory committee will meet on Sunday to make recommendations on how to prioritize the use of the single-dose vaccine. One major obstacle is the public’s need to know which form is superior.

Dr. Arnold Monto of the University of Michigan, who chaired an FDA advisory panel that unanimously voted Friday that the vaccine’s benefits outweigh its risks, said, “In this setting, whatever you can get, get.”

Data about how well all of the vaccines currently in use around the world perform is mixed, causing reports in some countries of people refusing to wait for one vaccine in favor of another.

The two-dose Pfizer and Moderna shots were 95 percent successful against symptomatic COVID-19 in the United States. When mild cases were introduced, J&J’s one-dose efficacy of 85 percent against extreme COVID-19 fell to 66 percent. However, there is no apples-to-apples comparison due to variations in when and where each company performed its studies, with Pfizer and Moderna’s studies completed before the spread of variants.

Collins of the National Institutes of Health claimed that there is no reason to choose one vaccine over another based on the facts.

“I guess the biggest question is whether or not it would protect me from being severely ill.” Collins expressed his view. “Will it prevent me from succumbing to this awful disease?” The good news is that they all say yes.”

In a separate broad trial, J&J is testing two doses of its vaccine. People who received the first dose will be given a second if a second dose were later found to be better, according to Collins.

It’s too early to say whether anyone who gets a mild or asymptomatic infection after vaccination can still spread the virus, according to the FDA.

Aside from the ease of a single shot, there are some distinct advantages. Local health authorities are considering using the J&J option in mobile vaccine clinics, homeless shelters, and even with sailors who spend months at a time on fishing vessels — areas where it’s impossible to predict if anyone would return in three to four weeks for a second vaccination.

In contrast to the Pfizer and Moderna vaccines, which must be frozen, the J&J vaccine is much simpler to treat, lasting three months in the refrigerator.

“We’re salivating at the thought of having more supply. “Right now, it is our limiting factor,” said Dr. Matt Anderson of UW Health in Madison, Wisconsin, where staffers were planning electronic health records, staffing, and vaccine storage in anticipation of soon providing J&J shots.

According to the FDA, no significant side effects were discovered in trials. The major side effects of the J&J shot, like other COVID-19 vaccines, are injection site discomfort, flu-like fever, weakness, and headache.

According to an FDA fact sheet for vaccine users, there is a “small risk” that people may have a serious allergic reaction to the injection, as has occurred in the past with Pfizer and Moderna vaccines. Such reactions are treatable, and vaccine recipients should be monitored for a limited period after receiving the injection.

For the time being, the vaccine has been approved for emergency use in adults 18 and older. However, J&J, like other manufacturers, is planning to explore how it works in adults before moving on to younger children later this year, as well as a study in pregnant women.

COVID-19 vaccines all teach the body to identify the new coronavirus by detecting the spikey protein that coats it. However, they are formed in very different ways.

J&J’s vaccine uses a cold virus as a Trojan horse to bring the spike gene into the body, where cells create harmless copies of the protein to brace the immune system for when the real virus arrives. It’s the same technology the company used to produce an Ebola vaccine, and it’s close to AstraZeneca’s COVID-19 vaccine and CanSino Biologics’ COVID-19 vaccine.

The mechanism of action of J&J’s vaccine

The Pfizer and Moderna vaccines use a different technology, a piece of genetic code known as messenger RNA, which encourages cells to generate those harmless spike copies.

The AstraZeneca vaccine, which is already in use in the United Kingdom and a number of other countries, is approaching the end of a major FDA-required study in the United States. Novavax, which uses a different technology based on lab-grown copies of the spike protein and has published preliminary results from a British study indicating good safety, is also in the works.

Some countries are using Sinovac and Sinopharm’s “inactivated vaccines,” which are made with killed coronavirus.

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WATCH: Broncos’ Pat Surtain II picks off Chargers’ Justin Herbert, again, returns it for a touchdown

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WATCH: Broncos’ Pat Surtain II picks off Chargers’ Justin Herbert, again, returns it for a touchdown

Have a day, Pat Surtain II.

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WATCH: Broncos’ Teddy Bridgewater evades Chargers’ Joey Bosa, connects with Eric Saubert for touchdown

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WATCH: Broncos’ Teddy Bridgewater evades Chargers’ Joey Bosa, connects with Eric Saubert for touchdown

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Run game carries Jets to 21-14 win over the Texans in Zach Wilson return

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Run games carries Jets to 21-14 win over the Texans in Zach Wilson return

HOUSTON — It was the definition of a team win for Gang Green. The offense was balanced, and the defense played lights out and the end result was a 21-14 win over the lousy Houston Texans.

Zach Wilson had a pedestrian day in his return to action as he went 14-for-24 for 145 yards with a rushing touchdown and an interception. Wilson wasn’t happy with his performance but elated for the victory.

“Feels really good,” Wilson said. “I wasn’t happy with how I performed. Just the ups and downs of it all. I gotta just keep going, it’s all part of the process. it feels really good to go home having a win. That’s the goal, to win the game.”

It was Wilson’s first game in a month, but the former BYU quarterback refused to blame his lackluster play on rust.

“I don’t blame anything on that,” Wilson said. “There’s no excuses. You got to really come out and play well.”

Late in the fourth quarter, Wilson appeared to tweak his knee on a scramble that caused him to limp to the sideline. But he claimed there was no legitimate issue and didn’t leave the game.

What helped propel the Jets offense to a win was the dominant run game that gashed the Texans for 157 yards.

Robert Saleh credited Jets offensive line coach and run game coordinator John Benton for creating a game plan to destroy the Texans run defense.

“JB put together a really cool plan and credit to the O-Line there,” Saleh said. “One of the challenges that we had this week for the offense was urgency and physicality at the line of scrimmage. And I felt like we were able to do that.”

The Jets answered the call. Against a loaded box, they ran for 105 yards with two touchdowns according to Next Gen Stats. That’s imposing your will.

Gang Green’s leading rusher, Michael Carter was out, but Tevin Coleman stepped up and ran for 67 yards. Austin Walter, who added 38 yards on nine carries, scored a key touchdown in the closing minutes of the first half.

The maligned defense, who had allowed over 380 yards of offense in five out of their last six games, held the Texans (2-9) to 202 yards and 14 points. Bryce Hall sealed the victory with a pass breakup on 4th-and-2 with two minutes remaining.

The impressive part was the resolve. They allowed 14 points and 157 yards by the end of the first half. But in the second half, they held the Texans offense to a scant 45 yards and zero points.

“I thought they were fantastic. I thought [Jeff] Ulbrich and the staff did great,” Saleh said. I thought the players, again, they’re getting better. And I thought this was a good one.”

One of the stars that contributed to the stalwart defensive effort was John Franklin-Myers, who had two sacks and an interception.

“Our coaches just preach we have to play our brand of football,” Franklin-Myers said. “l sometimes think things happen fast, just the momentum switches and stuff like that. But I think we did a good job of just staying locked in.”

It was a needed effort by the defense as the rookie quarterback took most of the first half to shake off the rust from missing four games with a sprained knee.

It was a tale of two halves for Wilson.

In the first half Wilson struggled. He was 6-for-12 for 44 yards with an interception. He looked jittery in the pocket and was inaccurate on a few of his throws that resulted in the ball skipping at his receivers’ feet.

On his second drive, he inexplicably threw an interception when he appeared to be scrambling. But right before he crossed the line of scrimmage, he flicked a pass to Ty Johnson, who wasn’t looking. It bounced off Johnson’s back and Tavierre Thomas intercepted the pass.

At that point Wilson was 1-for-6 for 11 yards with the pick. And the lone completed pass was a push pass behind the line of scrimmage to Elijah Moore on a jet sweep.

Even though Wilson didn’t blame rust for his struggle, it was clear as day: the No. 2 overall pick was rusty.

Five plays later, Texans QB Tyrod Taylor threw a touchdown pass to tight end Brevin Jordan to give Houston a 7-3 lead.

But right before the end of the half, trailing 14-3, Wilson finally settled down.

He went 5-for-6 for 33 yards to lead a touchdown drive to get Gang Green back in the game. Not an eye-popping stat line. But he converted a 3rd-and-9 to Ryan Griffin that kept the drive alive, and Walter scored a two-yard touchdown. The Jets successfully went for two to pull within 14-11.

In the second half, Wilson was much better. In the third quarter, his first pass was a rifle to Moore for a 22-yard gain on a curl route and that helped get Wilson comfortable.

That drive ended with a 4-yard rushing touchdown by Wilson to give the Jets the lead, 18-14. Not exactly setting the world on fire, but he doubled the first half yardage and got into a rhythm.

Overall, Wilson threw for 101 yards and went 8-for-12 in the second half.

The Jets offense sputtered in the fourth, but they were able to secure a 37-yard Matt Ammendola field goal with three and a half minutes to play and their defense finished the Texans off.

With the hype surrounding Wilson’s return it was the run game and the defense that played lights out and carried the rookie to a win.

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