49ers vs. Patriots prediction, odds, line, spread, time: 2024 NFL picks, Week 4 best bets from advanced model

The defending NFC champions, the San Francisco 49ers, is likely to be in disaster mode getting into their Week 4 matchup at residence towards the New England Patriots. San Francisco (1-2) has been with out key offensive weapons, together with star operating again Christian McCaffrey, and misplaced two consecutive highway video games, together with to the Rams final week, 27-24. New England (1-2) fell on the Jets final Thursday, 24-3, in its most up-to-date contest. The 49ers gained the final matchup between the 2 groups, 33-6, in October 2020.

Kickoff from Levi’s Stadium is ready for 4:05 p.m. ET. San Francisco is a ten.5-point favourite within the newest 49ers vs. Patriots odds, per SportsLine consensus, whereas the over/underneath for whole factors is 42. Earlier than making any Patriots vs. 49ers picks, it is advisable see the NFL predictions and betting recommendation from the confirmed laptop mannequin at SportsLine.

The mannequin, which simulates each NFL sport 10,000 instances, is up nicely over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin enters Week 4 of the 2024 NFL season on an unbelievable 188-130 run on top-rated NFL picks that dates again to the 2017 season. Additionally it is on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The mannequin additionally ranked within the prime 10 on NFLPickWatch 4 of the previous six years on straight-up NFL picks and beat greater than 94% of CBS Sports activities Soccer Decide’em gamers 4 instances throughout that span. Anybody who has adopted it’s means up.

Now, the mannequin has set its sights on Patriots vs. 49ers and simply locked in its picks and NFL Week 4 predictions. You’ll be able to head to SportsLine now to see the mannequin’s picks. Listed below are a number of NFL odds and betting traces for unfold, cash line and over/underneath:

• 49ers vs. Patriots unfold: 49ers -10.5
• 49ers vs. Patriots over/underneath: 42 factors
• 49ers vs. Patriots cash line: 49ers -595, Patriots +438
• 49ers vs. Patriots picks: See picks at SportsLine

Why the Patriots can cowl

Can the Patriots pull one other stunning highway upset early within the season? In Week 1, they defeated the Bengals 16-10 regardless of being a 7.5-point underdog. With the 49ers having struggled of late, they may not have turned issues in time for this matchup, particularly being with out a number of key items on offense and protection.

New England will probably should lean on their dashing assault led by Rhamondre Stevenson. Regardless of a dud in Week 3 towards the Jets, Stevenson rushed for a mixed 201 yards and two scores in Weeks 1-2 mixed. He can be leaned on closely when the sport is shut with the gameplan prone to be conserving San Francisco’s high-powered offense off the sector. See which crew to select right here.

Why the 49ers can cowl

Even with out vast receiver Deebo Samuel, tight finish George Kittle and star operating again Christian McCaffrey, the 49ers seemed to be in full management final week in Los Angeles. However they squandered a 24-14 lead within the fourth quarter, falling to the Rams because the offense could not make a giant play down the stretch. Quarterback Brock Purdy performed very nicely although, throwing for 292 yards and three touchdowns within the defeat.

Within the absence of Samuel and Kittle, WR Jauan Jennings joined Brandon Aiyuk within the beginning lineup and torched the Rams’ secondary. Jennings caught 11 passes for 175 yards and three touchdowns, practically singlehandedly main the 49ers to victory. Towards a strong New England secondary, Aiyuk and Jennings must make performs in house to assist San Francisco’s offense. Operating again Jordan Mason has additionally been a pleasing shock, having rushed for 324 yards and two touchdowns so far with McCaffrey out. See which crew to select right here.

The way to make Patriots vs. 49ers picks

The mannequin has simulated New England vs. San Francisco 10,000 instances and the outcomes are in. It’s leaning Underneath on the purpose whole, and it additionally says one facet of the unfold hits over 50% of the time. You’ll be able to solely see the mannequin’s Patriots vs. 49ers decide at SportsLine.

So who wins San Francisco vs. New England on Sunday, and which facet of the unfold hits over 50% of the time? Go to SportsLine proper now to see which facet of the Patriots vs. 49ers unfold you ought to be throughout Sunday, all from the mannequin on a 188-130 roll on its top-rated NFL picks, and discover out.