Get your popcorn ready! Week 1 of the NFL season is upon us.
The 2026 season kicks off in style with a a Super Bowl rematch between the defending champion Seattle Seahawks and the New England Patriots at Lumen Field in Seattle. The Seahawks, who disposed of the Patriots 29-13 to cap last season’s championship run, are 3.5-point favorites for Wednesday night’s opener.
The action continues one night later when the Los Angeles Rams host the San Francisco 49ers on Thursday night in a clash of NFC West rivals. Both teams went 12-5 last season, and both teams’ seasons came to an end in the playoffs at the hands of the Seahawks. The Rams are a 3.5-point favorite over the 49ers.
Sunday gives us a 13-game slate, with the Buffalo Bills-Houston Texans matchup highlighting the early afternoon games. The Texans come in as slight favorites. The Sunday night game features a classic NFC East rivalry, as the Dallas Cowboys visit the New York Giants as 3-point road favorites.
A whopping 12 Week 1 games have spreads of 3.5 points or less. The Los Angeles Chargers are the biggest favorite of the week, laying 10 points to the Arizona Cardinals. The Tampa Bay Buccaneers-Cincinnati Bengals matchup has the highest total of the week at 50.5.
The week wraps up with Patrick Mahomes making his comeback from a torn ACL when the Kansas City Chiefs (-3, 42.5) host the Denver Broncos on “Monday Night Football” (8:15 ET on ABC/ESPN).
Here’s a look at the odds for every Week 1 game.
Note: Odds by DraftKings and subject to change.
Jump to:
NE-SEA | SF-LAR | TB-CIN | NO-DET
NYJ-TEN | BAL-IND | ATL-PIT | CHI-CAR
CLE-JAX | BUF-HOU | MIA-LV | GB-MIN
WSH-PHI | ARI-LAC | DAL-NYG | DEN-KC
Wednesday
New England Patriots at Seattle Seahawks (-3.5)
8:20 p.m. ET on NBC, Lumen Field, Seattle
Moneyline: Seahawks -180, Patriots +150
Total: 45.5 points
FPI favorite: Seahawks by 3.4, 61.1% to win outright
Thursday
San Francisco 49ers vs. Los Angeles Rams (-3.5)
8:35 p.m. ET on Netflix, Melbourne Cricket Ground, Melbourne, Australia
Moneyline: Rams -185, 49ers +154
Total: 48.5 points
FPI favorite: Rams by 2.9, 60.5% to win outright
Sunday
Tampa Bay Buccaneers at Cincinnati Bengals (-3.5)
1 p.m. ET on FOX, Paycor Stadium, Cincinnati
Moneyline: Bengals -198, Buccaneers +164
Total: 50.5 points
FPI favorite: Bengals by 3.2, 61.6% to win outright
New Orleans Saints at Detroit Lions (-7)
1 p.m. ET on FOX, Ford Field, Detroit
Moneyline: Lions -290, Saints +235
Total: 49.5 points
FPI favorite: Lions by 6.8, 71.9% to win outright
Check out each team’s futures odds here. For the latest, visit DraftKings
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New York Jets at Tennessee Titans (-1.5)
1 p.m. ET on CBS, Nissan Stadium, Nashville, Tenn.
Moneyline: Titans -125, Jets +105
Total: 39.5 points
FPI favorite: Titans by 2.1, 57.6% to win outright
Baltimore Ravens (-3) at Indianapolis Colts
1 p.m. ET on CBS, Lucas Oil Stadium, Indianapolis
Moneyline: Ravens -162, Colts +136
Total: 47.5 points
FPI favorite: Ravens by 2.4, 59.0% to win outright
Atlanta Falcons at Pittsburgh Steelers (-3.5)
1 p.m. ET on FOX, Acrisure Stadium, Pittsburgh
Moneyline: Steelers -185, Falcons +154
Total: 42.5 points
FPI favorite: Steelers by 2.6, 58.9% to win outright
Chicago Bears (-3) at Carolina Panthers
1 p.m. ET on FOX, Bank of America Stadium, Charlotte, N.C.
Moneyline: Bears -148, Panthers +124
Total: 46.5 points
FPI favorite: Bears by 2.6, 59.6% to win outright
Cleveland Browns at Jacksonville Jaguars (-7.5)
1 p.m. ET on CBS, EverBank Stadium, Jacksonville, Fla.
Moneyline: Jaguars -380, Browns +300
Total: 40.5 points
FPI favorite: Jaguars by 7.8, 77.3% to win outright
Buffalo Bills at Houston Texans (-1.5)
1 p.m. ET on CBS, NRG Stadium, Houston
Moneyline: Bills -118, Texans -102
Total: 44.5 points
FPI favorite: Bills by 1.1, 53.5% to win outright
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Miami Dolphins at Las Vegas Raiders (-3.5)
4:25 p.m. ET on FOX, Allegiant Stadium, Las Vegas
Moneyline: Raiders -185, Dolphins +154
Total: 40.5 points
FPI favorite: Raiders by 2.8, 59.8% to win outright
Green Bay Packers at Minnesota Vikings (-1.5)
4:25 p.m. ET on CBS, U.S. Bank Stadium, Minneapolis
Moneyline: Vikings -122, Packers +102
Total: 46.5 points
FPI favorite: Packers by 1.8, 56.6% to win outright
Washington Commanders at Philadelphia Eagles (-4.5)
4:25 p.m. ET on FOX, Lincoln Financial Field, Philadelphia
Moneyline: Eagles -205, Commanders +170
Total: 44.5 points
FPI favorite: Eagles by 4.9, 66.5% to win outright
Arizona Cardinals at Los Angeles Chargers (-10)
4:25 p.m. ET on CBS, SoFi Stadium, Inglewood, Calif.
Moneyline: Chargers -625, Cardinals +455
Total: 47.5 points
FPI favorite: Chargers by 9.6, 80.8% to win outright
Dallas Cowboys (-3) at New York Giants
8:20 p.m. ET on NBC, MetLife Stadium, East Rutherford, N.J.
Moneyline: Cowboys -155, Giants +130
Total: 48.5 points
FPI favorite: Cowboys by 2.0, 57.2% to win outright
Monday
Denver Broncos at Kansas City Chiefs (-3)
8:15 p.m. ET on ESPN/ABC, GEHA Field at Arrowhead Stadium, Kansas City, Mo.
Moneyline: Chiefs -155, Broncos +130
Total: 43.5 points
FPI favorite: Chiefs by 2.5, 58.5% to win outright